Tadalafil: Uses, Dosage and Side Effects

Tadalafil is the generic name for Phosphodiesterase-5 inhibitors of PDE-5 inhibitors. Cialis and Adcirca are the two brand names under which Tadalafil is sold. Cialis is used to treat erectile dysfunction and benign prostatic hyperplasia. Adcirca is used to treat high blood pressure in the lungs, a condition called pulmonary arterial hypertension. Tadalafil Cialis increases blood flow to the penis during sexual stimulation, thereby improving erection. Concerning BPH, it relieves symptoms such as difficulty in commencing urination, a weak stream of urine and urges to urinate frequently by relaxing the smooth muscles of the prostate and bladder. Tadalafil Adcirca, on the other hand, works by relaxing the blood vessels in the lungs to lower pulmonary blood pressure.

How does Tadalafil work?

It is essential to know what Phosphodiesterase-5 or PDE-5 is to understand the mode of action of Tadalafil. PDE-5 is an enzyme that accelerates biochemical reactions. It is present in both the spongy erectile tissue of the penis called corpus cavernosum and the smooth muscles of the blood vessels in the lungs.

Erectile dysfunction is caused by the lowering of cyclic guanosine monophosphate or cGMP in the corpus cavernosum. cGMP is produced by Nitric Oxide, which is itself made when the man is sexually stimulated. cGMP causes the smooth muscles of the corpus cavernosum to relax, thereby causing blood to flow to the penis leading to an erection. PDE-5 enzyme lowers cGMP in the corpus cavernosum, which causes the muscles to be less relaxed, leading to lesser blood flow into the penis, leading to erectile dysfunction. Tadalafil acts by inhibiting the activity of PDE-5, which directly increases cGMP levels in the corpus cavernosum, thereby increasing blood flow to the penis.

In PAH, tadalafil adcirca increases the cGMP levels in the smooth muscles of the blood vessels in the lungs, which causes relaxation of the blood vessels and lowering of the pulmonary blood pressure.

Tadalafil Cialis’ action concerning limiting the symptoms of BPH is not known. It might act by reducing cell proliferation to lessen the symptoms of BPH. Specific theories suggest that Tadalafil works by relaxing the smooth muscles, bladder and prostate. A set of experts also believe that Tadalafil reduces the symptoms of BPH by acting on the nervous system.

What is Tadalfil Liquid?

Tadalafil usually comes in the form of tablets. But tadalafil liquid is also being sold by many pharmacies. More specifically, Cialis is available in liquid form. Liquid Tadalafil is easier to ingest for men.

Suspension and Jelly are two forms of liquid Tadalafil. Tadalafil suspension contains the main active ingredient tadalafil in a carrier liquid which is usually water. Flavouring can be added to hide the taste. Tadalafil Jelly is gelatin containing Tadalafil. The gelatin is usually flavoured.

Liquid tadalafil is faster acting as compared to tablet tadalafil. This is because Tadalafil is already dissolved in the liquid and gets absorbed in the stomach faster. There is no need for water to consume liquid Tadalafil. People who have problems swallowing tablets or have undergone throat or mouth surgery cannot take Tadalafil in tablet form but have no problem taking liquid Tadalafil.

The dosage of liquid Tadalafil depends upon whether you are taking it daily or just when you want to indulge in sexual activity. If it is to be taken as and when required, then the starting dose should be 10mg which can be increased to 20mg if the desired level of satisfaction is not achieved. If you need it daily, the starting dosage is 2.5 mg/day, which can be increased to 5 mg/day but should not exceed this limit in a day. Tadalafil should not be taken more than once a day.

Liquid tadalafil is not FDA approved and comes as a research chemical.

Level of efficacy

There is no difference between liquid Tadalafil and tablet tadalafil in terms of efficacy. The half-life of Tadalafil is 15-20 hours regardless of whether you are taking it in tablet or liquid form. This implies that the chemical remains in the body for a longer time than other PDE-5 inhibitors. It remains effective for as long as 30 hours.

Side effects

There are specific side effects associated with liquid Tadalafil. These include indigestion, headache, nausea, flushing, diarrhoea, cough and pain in the back, hands, legs and stomach. These side effects are not severe and subside, but if they persist for a long time, then medical help are necessary.

Some side effects are severe, necessitating emergency treatment. These include erection longer than 4 hours, loss of vision, blurred vision, chest pain, dizziness and difficulty in breathing. You can know about epistaxis.

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