This one the most "human" reaction we have seen so far from Yakumo. But she will handle it somehow - the problem is Harima right know.
The way he goes, he will start something new and will probably fail. For now he will forget that Ojou had destroyed his manga since most important thing for him was Tenma and he somehow could express those feelings - but what if he wakes up and see that he chose wrong path ? He could just start randomly put guilt on someone. I think Harima needs Yakumo here - the same way she helped him at school festival.