This has been stated before but this manga should be called Sasuke.
After Sasuke kills Itachi, he'll go after Madara cause Itachi was Madara's accomplice, Now Madara is also the head of Akatsuki, who also happens to have a grudge against Konoha cause the first Hokage beat him back in the old days. Therefore he's going to want do destroy Konoha. From this we know that after a long and drawn out manga with Sasuke hunting Madara/Madara pwning Sasuke a few times, Sasuke will eventually beat Madara, saving Konoha in the process cause Madara was the final badass wanting to destroy Konoha.
This IS the main plot of 'Naruto'.
Now Naruto? He's the side character. He wants to be Hokage blah blah blah, he'll most likely end up Hokage, but only after Sasuke inevitably saves Konoha by killing Madara. He'll also pwn Pain but pain is a minor character. Later on Sasuke and Naruto will kiss and make up and live happily ever after, but be rest assured. Sasuke is the one who does anything really major. If you think about it, Naruto is the side character who just happens to have more connections then say, Shino.