That depends on the comic. Some of them you don't need to be a gamer to get, however many, are like this one;
To me this comic is absolutely hilarious:
http://www.penny-arcade.com/comic/1999/11/22
However, it will not have the same effect on anyone who did not bear witness to the hypemachine and terrible failure of egomaniac John Romero. (Id software or not, some people need to notice when their stay in the industry is over. That is, the day they become more interested in playing games than they are in making them. Carmack became the face of Id software in my mind.)
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